Hyperostosis Frontalis Interna is characterized by the thickening of the frontal bone of the skull. It is not clear that this disorder is actually rare. Some clinicians. Hyperostosis frontalis interna is characterised by benign overgrowth of the inner table of the frontal bone. It is seen most commonly in older females. The etiology . chronic, severe anaemia · hyperparathyroidism · acromegaly · osteopetrosis · hyperostosis frontalis interna; long-term phenytoin use; genetic diseases (rare).

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This excess growth can only be seen in an x-ray.

Check for errors and try again. The skull thickening may be sessile or nodular, and may affect the bone in a focal or diffuse manner. Case 5 Case 5. This disorder presents itself most often among the middle-aged and elderly but has also been found in adolescents.

Hyperostosis Frontalis Interna – NORD (National Organization for Rare Disorders)

Support Radiopaedia and see fewer ads. The enlargement of soft tissue, especially of the heart, is a serious feature of this disorder. Case 2 Case 2.


Hyperostosis Frontalis Interna is characterized by the ffrontal of the frontal bone of the skull. Farinelli was castrated before puberty to preserve the treble pitch of the boy’s voice into adult life. Interns this hospital stay the presence of grade I obesity, hyperglycemia, hypertriglyceridemia and hyperuricemia was documented.

Years Published, In particular, the frontal bone was affected by severe hyperostosis frontalis interna HFI. Paget’s disease Case 4: Hyperostosis frontalis interna is characterised by benign overgrowth of the inner table of the frontal bone.

Rare Disease Database

Excessive thirst is the major symptom of this disorder. The condition is generally of no clinical significance and an incidental finding. Galactorrhea is a condition in which there is a spontaneous flow of milk from the nipple. Ross AH, et al.

The content of the website and databases of the National Organization for Rare Disorders NORD is copyrighted and may not be reproduced, copied, downloaded or disseminated, in any way, for any commercial or public purpose, without prior written authorization and approval from NORD.

Camurati-Engelmann disease Case 7: Many people have no apparent symptoms. Onset of this disorder commonly occurs during young adulthood although it can occur at any age and is extremely variable in degree of severity.


Hershkovitz I, et al. The lack of this hormone on the kidney causes excretion of excessive quantities frontla very dilute but otherwise normal urine. The major feature of Hyperostosis Frontalis Interna is excessive growth or thickening of the frontal bone of the head. The following disorders have been found in association with Hyperostosis Frontalis Interna.

You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. It is typically bilateral and symmetrical, and may extend to involve the parietal bones. Case 8 Case 8. Increased serum alkaline phosphatase and elevated serum calcium may occur.

Case 9 Case 9. About Blog Go ad-free. Case 4 Case 4. Log in Sign up. Unable to process the form. Hyperostosis frontalis interna HFI is a bone overgrowth on the inside of the frontal bone.